If you are already using an Omega-3 supplement, specialized pro-resolving mediators (SPMs) supplements or even a high-fat diet, you probably understand all the health benefits of supplementing our body with essential fatty acids. However, for certain populations, there is still more you can do to enhance the benefits of these. Omega Optimizer helps support your body get the full benefit of Omega supplementation optimizing DHA, and supporting delivery of PC and LPC.
Omega Optimizer was created with the idea of maximizing the effect of omega-3 supplementation by helping with many of the downstream biochemical processes which make omega-3’s so beneficial. One way that Omega supplementation helps is by helping replace depleted phosphatidylcholine (PC) via endogenous pathways.
This is particularly prevalent where sustained oxidative stress is present (such as in athletes or aging populations). There, cellular and circulating phosphatidylcholine (PC) levels are depleted as PC is being incorporated into damaged cell membranes. To help restore proper levels of PC, PC can be regenerated via phosphatidylethanolamine (PE) or lysophosphatidylcholine (LPC).
However, as PE and LPC convert to PC to replace the PC we have damaged in our cells, we start to have deficiencies of these compounds as well. This is a problem as LPC is central to numerous physiological pathways, and reduced levels of LPC are a hallmark of various diseases and disorders.
For example, reduction in mental/cognitive performance, vision impairment, and lack of immune activation have been associated with low concentrations of LPC. Furthermore, diabetes and dyslipidemia are typically tightly correlated with low levels of LPC (See here, here, and here).
Moreover, docosahexaenoic acid (DHA) is an essential fatty acid that is used in neural and retinal tissues, and transport of DHA into those tissues uses LPC!
Unfortunately, dietary supplementation with polyunsaturated fatty acids (PUFAs), LPC, DHA, and LPC-DHA is relatively ineffective as these entities are subject to intestinal enzymes, lipid transport proteins, and transesterification. In order to help regenerate this LPC deficiency, we must do something else!
Omega optimizer addresses this issue in 2 steps:
It decreases the inflammatory lipids and increases DHA: SmartPrime effectively and synergistically influences lipid metabolism via “biased” inhibition of the enzyme delta-5 desaturase (D5D). This inhibition is important because it blocks an enzyme which can cause omega-3s to be broken down into molecules which actually cause inflammation in our body called eicosanoid arachidonic acid (AA). By blocking this, our bodies can use the omega’s in a way which is more beneficial to our health.
It replenishes phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) to improve delivery to cell types that need it: SmartPrime also uses a blend of methyl donors which enhances the conversion of omega-3s to compounds (such as PC and 18:2 LPC) which can help this process but also enhance the uptake and transport of omega-3 fatty acids into the cell. This improves our cell function which helps almost every system in the body such as our blood vessels, heart, eyes, and brain, but it especially helps our mitochondria synthesize a much needed protein which is necessary for energy production. It also makes sure the DHA, one of the main omega-3 types is available to be transported into nerve, neural and retinal tissue!
AstraGin® is all about improving absorption in the body.
AstraGin® is a 100% natural compound made up of two highly fractionated medicinal plants, Astragalus membranaceus and Panax notoginseng. These herbs have been used in Traditional Chinese Medicine (TCM) historically and boast a wide range of health benefits. Astragalus membranaceus contains certain polysaccharides, saponins, and astragalosides which play a role in the absorption enhancement mechanism in the human body. It was selected because of the data showing it Increases polyunsaturated fatty acid (derived from flax oil and fish oil) absorption by 58% and 100%
Together, this omega-3 optimizer makes sure you are maximizing the benefit of omega-3 to multiple tissues all at once!